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Istituto Rinaldi Fontani · REAC Inside Blue Zone network

Energy metabolism and ageing: why we feel more tired

8 May 2026 Prof. Dr Salvatore Rinaldi

Energy metabolism and ageing: why we feel more tired

Energy metabolism is the basis of every vital function. As we age, this system may become less efficient. Cells produce energy less efficiently, and the body finds it harder to adapt to environmental demands.

This often results in diffuse symptoms such as persistent fatigue, reduced recovery capacity and decreased performance. Metabolism is not only a biochemical process, but a system regulated by complex signals that coordinate cellular activity.

The most advanced strategies in longevity medicine today focus on improving metabolic efficiency by supporting regulatory mechanisms. Supporting metabolism means supporting the body’s ability to maintain its vital functions over time.

In this context, projects such as REAC Inside Blue Zone aim to act on the body’s energy regulation mechanisms, with the goal of promoting greater metabolic efficiency over time.

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