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Istituto Rinaldi Fontani · REAC Inside Blue Zone network

Silent chronic inflammation: what it is and why it accelerates ageing

8 May 2026 Prof. Dr Salvatore Rinaldi

Silent chronic inflammation: what it is and why it accelerates ageing

Inflammation is a key process for survival. However, when it remains active at low intensity over time, it can become a factor in biological deterioration. This condition is known as silent chronic inflammation.

Unlike acute inflammation, it does not produce obvious symptoms. It does not cause immediate pain or easily recognisable clinical signs, but acts progressively and continuously. A considerable body of evidence indicates that this condition is involved in the main processes associated with ageing, contributing to reduced cellular efficiency and loss of adaptive capacity.

The causes are multifactorial: prolonged stress, unbalanced diet, sedentary lifestyle and environmental factors. For this reason, research is moving towards strategies capable of acting upstream of inflammatory processes, promoting the rebalancing of biological regulation mechanisms.

Understanding and addressing silent chronic inflammation means acting on one of the main drivers of ageing. This is the context for clinical approaches developed to act on biological regulation mechanisms, such as the project REAC Inside Blue Zone, which translates this knowledge into structured protocols aimed at rebalancing inflammatory processes.

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